Presentations and Patents

Dr. Snow – Selected Presentations Related to PTI-00703^® Cat’s Claw

 

1. McCurley D., Castillo G.M. and Snow A.D. Therapeutic implications of PTI-00703^®: Presentation at the 6th International Conference on Alzheimer’s Disease and Related Disorders, Amsterdam, July 18-23, 1998.

2. Snow A.D., Castillo G.M., Cummings J.A., Vrablic A.S. and DeSantis D. A new dietary supplement containing PTI-00703^®. Presentation at Experimental Biology ‘99, Washington, D.C., April 1999.

3. Snow A.D., Cummings J.A., Castillo G.M., Vrablic A.S. and DeSantis D.A. Further efficacy of PTI-00703^®: A dietary supplement which causes a dose-dependent inhibition of brain amyloid deposition in a rodent model. Presentation at Experimental Biology ‘99, Washington, D.C., April 1999.

4. Castillo G.M., J.A. Cummings and Snow A.D. Further efficacy of PTI-00703^®: A derivative from the amazon rain forest woody vine Uncaria tomentosa (Cat’s claw) that is a potent inhibitor of beta-amyloid protein fibrillogenesis. Oral presentation at the 29th Annual Meeting Society for Neuroscience, Miami, Florida, Oct 23-28, 1999.

5. Cummings J.A., Castillo G.M., Choi P.Y., and Snow A.D. Disruption of pre-deposited Aß 1-42 fibrils by PTI-00703^® (Cat’s claw derivative) in a rodent model of Aß fibrillogenesis. Poster presentation, Washington, D.C. July 9-13, 2000.

6. Castillo G.M., Kirschner D.A., Yee A.G., and Snow A.D. Electron microscopy and x-ray diffraction studies further confirm the efficacy of PTI-00703^® (Cat’s claw derivative) as a potent inhibitor of beta-amyloid protein fibrillogenesis. Oral Presentation, Washington, D.C. July 9-13, 2000.

7. Snow A.D., Choi P.Y., Cummings J.A., Wood S., Kirschner D.A., and Castillo G.M. Isolation and testing of the amyloid-inhibiting ingredients derived from the natural beta-amyloid protein fibrillogenesis inhibitor PTI-00703^®. Presentation at the 30th Annual Meeting Society for Neuroscience, New Orleans, LO, Nov 4-9, 2000. Soc. Neurosc. Abst. 26: 299.3, 2000.

8. Snow A.D., Rockenstein E., Cummings J.A., Castillo G.M., Choi P.Y., and Masliah E. PTI-777 treatment causes a potent reduction of amyloid plaque burden in a transgenic mouse model. Presentation at the 31st Annual Meeting Society for Neuroscience, San Diego, CA, Nov 10-15, 2001.

9. Cummings J.A., Kastin A.J., Pan W., Maresh G.A., Choi P.Y., Castillo G.M., and Snow A.D. Penetration of PTI-777 (amyloid inhibitory components of Uncaria tomentosa) across the blood-brain-barrier. Presentation at the 31st Annual Meeting Society for Neuroscience, San Diego, CA, Nov 10-15, 2001.

10. Castillo G., Kastin A, Pan W., Maresh G., Cummings J., Choi P., Nguyen B., Rockenstein E., Masliah E.,
  and Snow A.D. Penetration of PTI-777 (amyloid inhibiting components of Uncaria tomentosa) across the
  blood-brain-barrier. Presentation, Stockholm, Sweden, July 2002.

11. Snow A.D., Cummings J.A., Nguyen B.P., Lake T.P., Choi P.Y., Sanders V.J., Castillo G.M., Wood S.,
  Rockenstein E., and Masliah E. Amyloid plaque burden is markedly reduced in a transgenic mouse
  model by the natural plant extract PTI-777. Presentation at the 33nd Annual Meeting for Neuroscience,
  New Orleans, LO, Nov 2003.

12. Snow A.D., Cummings J.A., Nguyen B.P., Castillo G.M., Choi P.Y., Rockenstein E., and Masliah, E. Marked
  clearance of amyloid plaque burden and improved memory in a transgenic mouse model by PTI-0038 (A
  single component isolated from the natural plant extract PTI-777). Oral presentation, Tours, France,
  April 2004.

13. Kirchner D.A., Gross A.A.R., Hidalgo M. M., Inouye H., Gleason K.A., Abdelsayed G.A., Castillo G.M.,
  Snow A.D., Pozo-Ramajo A., Petty S.A., and Decatur S.M. Fiber diffraction as a screen for amyloid
  inhibitors. Current Alzheimer Res. 5:288-307, 2008

14. Snow A.D., Cummings J., Yadon M., Lake T., Hudson M., Jacobson E., Hu Q., Cam J., Weigele M., Kumar
  A., Masliah E., Rockenstein E., Wolozin B., Runnels S., and Esposito L. Novel ways to reduce protein
  aggregation. Invited Oral Presentation, San Diego, CA, Feb 2011.

15. Snow A.D., Castillo G.M., Cummings J., Lake T., Hu Q., Esposito L.A., Hanson K.L., Chong T.A., and Cam J.
  Development of “Cognitive Clarity™”: A unique dietary supplement for reduction of brain “plaques and
  tangles” and enhancement of memory, focus and concentration. 12th International Conference, Nice,
  France, March 2015.

 

Intellectual Property Related to Percepta^® and/or its Ingredients:

Backed by Over 50 Issued Patents

 

1. United States 6,264,994 Issued: 07/24/2001 Inventors: Castillo, Snow and Desantis.

2. United States 6,346,280 Issued: 02/12/2002 Inventors: Castillo and Snow.

3. New Zealand 528322 Issued: 07/07/2005 Inventors: Snow, Castillo, Choi and Nguyen.

4. United States 6,929,808 Issued: 08/16/2005 Inventors: Castillo, Choi, Nguyen and Snow.

5. United States 6,939,570 Issued: 09/06/2005 Inventors: Snow and Castillo.

6. Europe 1019044 Issued: 04/11/2007 Inventors: Castillo and Snow.

7. Belgium 1019044 Issued: 04/11/2007 Inventors: Castillo and Snow.

8. United States 7,285,293 Issued: 10/23/2007 Inventors: Castillo, Choi, Nguyen and Snow.

9. Europe 124435 Issued: 11/14/2007 Inventors: Castillo, Choi and Snow.

10. Austria 124435 Issued: 11/14/2007 Inventors: Castillo, Choi and Snow.

11. Belgium 1233325 Issued: 11/14/2007 Inventors: Castillo, Choi and Snow.

12. Switzerland 1244435 Issued: 11/14/2007 Inventors: Castillo, Choi and Snow.

13. Germany 1244435 Issued: 11/14/2007 Inventors: Castillo, Choi and Snow.

14. Denmark 124435 Issued: 11/14/2007 Inventors: Castillo, Choi and Snow.

15. Denmark 1019044 Issued: 04/11/2007 Inventors: Castillo, Choi and Snow.

16. France 1019044 Issued: 04/11/2007 Inventors: Castillo, Choi and Snow.

17. Netherlands 1019044 Issued: 04/11/2007 Inventors: Castillo, Choi and Snow.

18. Ireland 1019044 Issued: 04/11/2007 Inventors: Castillo, Choi and Snow.

19. Italy 1019044 Issued: 04/11/2007 Inventors: Castillo, Choi and Snow.

20. Sweden 1019044 Issued: 04/11/2007 Inventors: Castillo, Choi and Snow.

21. Chile 1019044 Issued: 04/11/2007 Inventors: Castillo, Choi and Snow.

22. Great Britain 1019044 Issued: 04/11/2007 Inventors: Castillo, Choi and Snow.

23. Germany 1019044 Issued: 04/11/2007 Inventors: Castillo, Choi and Snow.

24. Spain 124435 Issued: 04/11/2007 Inventors: Castillo, Choi and Snow.

25. France 1244425 Issued: 04/11/2007 Inventors: Castillo, Choi and Snow.

26. Great Britain 1808169 Issued: 04/11/2007 Inventors: Castillo, Choi and Snow.

27. Ireland 1244435 Issued: 04/11/2007 Inventors: Castillo, Choi and Snow.

28. Netherlands 1244435 Issued: 04/11/2007 Inventors: Castillo, Choi and Snow.

29. Sweden 124435 Issued: 04/11/2007 Inventors: Castillo, Choi and Snow.

30. United States Issued: 04/11/2007 Inventors: Castillo, Choi and Snow.

31. Austria 1019044 Issued: 04/11/2007 Inventors: Castillo, Snow, and Desantis.

32. United States 7,314,642 Issued: 01/01/2008 Inventors: Castillo, Choi, Nguyen and Snow.

33. Australia 20022501 Issued: 03/13/2008 Inventors: Castillo, Nguyen, Choi, Larsen, Lorimer and Snow.

34. Australia 20022792 Issued: 04/02/2009 Inventors: Castillo, Nguyen, Choi, Larsen, Lorimer and Snow.

35. Japan 4370072 Issued: 09/04/2009 Inventors: Castillo, Choi and Snow.

36. Japan 4380991 Issued: 10/02/2009 Inventors: Castillo, Nguyen, Choi, Larsen, Lorimer and Snow.

37. Japan 4386470 Issued: 10/09/2009 Inventors: Castillo and Snow.

38. Canada 2392709 Issued: 03/23/2010 Inventors: Castillo, Choi and Snow.

39. United States 7,754,250 Issued: 07/13/2010 Inventors: Castillo and Snow.

40. Japan 4708675 Issued: 03/25/2011 Inventors: Castillo and Snow.

41. Canada 2441099 Issued: 04/19/2011 Inventors: Castillo, Nguyen, Choi, Larsen, Lorimer and Snow.

42. Canada 2499549 Issued: 01/24/2012 Inventors: Castillo, Nguyen, Choi, Larsen, Lorimer and Snow.

43. Europe 1808169 Issued: 05/30/2012 Inventors: Castillo, Choi, and Snow.

44. Switzerland 1808169 Issued: 05/30/2012 Issued: Inventors: Castillo, Choi and Snow.

45. France 1808169 Issued: 05/30/2012 Inventors: Castillo, Choi and Snow.

46. Great Britain 1808169 Issued: 05/30/2012 Inventors: Castillo, Choi and Snow.

47. Ireland 1808169 Issued: 05/30/2012 Inventors: Castillo, Choi and Snow.

48. Canada 2427661 Issued: 05/28/2013 Inventors: Castillo, Choi, Nguyen and Snow.

49. Japan 5366473 Issued: 09/20/2103 Issued (delete) Inventors: Castillo, Choi and Snow.

50. Canada 2686468 Issued: 01/28/2014 Inventors: Castillo, Choi and Snow.

51. United States 9,133,176 Issued: 09/15/2015 Inventors: Castillo, Nguyen, Choi, Larsen, Lorimer and Snow.

52. United States 10,307,454 B2 Issued: 06/04/2019 Composition and methods for the treatment of plaques and tangles in humans and animals. Inventors: Cam, Lake, Hu, Cummings and Snow.

53. United States 10,350,258 B2 Issued: 07/16/2019 Composition and methods for the treatment of plaques and tangles in humans and animals. Inventors: Cam, Lake, Hu Cummings and Snow

54. PCT/US2016/019572 National Entry. Composition and methods for the treatment of plaques and tangles in humans and animals. Inventors: Cam, Lake, Hu, Cummings, and Snow.