Plant-Based Ingredients
Plant-Based Ingredients
Plant-Based Ingredients
We go to the ends of the earth for brain health so you don't have to.
We go to the ends of the earth for brain health so you don't have to.
We go to the ends of the earth for brain health so you don’t have to.
Patented PTI-00703® cat’s claw from the Amazon rain forest. Oolong MemorTea® extract. We go to the ends of the earth for brain health so you don’t have to. Percepta® is made from a natural plant-based blend that’s unlike anything else in the world of memory support. Our PTI-00703® extract is from cat’s claw (Uncaria tomentosa) that grows in the Peruvian rain forest. MemorTea (Camellia sinensis) derived from oolong tea is sourced from the Guan Yin mountains in China.
Cat’s claw is named for its distinctive claw-like thorns, which project from the base of its leaves. PTI-00703® Cat’s claw: “PTI-00703® cat’s claw” is a proprietary aqueous extract obtained from the Peruvian rain forest woody vine (also known as Uncaria tomentosa or Una de gato). This slow-growing woody vine is indigenous to the Amazon rain forest and other tropical areas of South and Central America.
The ingredients in Percepta® and their background
The ingredients in Percepta® and their background
Patented PTI-00703® Cat’s claw from the Amazon rain forest. Oolong MemorTea® extract. We go to the ends of the earth for brain health so you don’t have to. Percepta® is made from a natural plant-based blend that’s unlike anything else in the world of memory support. Our PTI-00703® extract is from cat’s claw (Uncaria tomentosa) that grows in the Peruvian rain forest. MemorTea® (Camellia sinensis) derived from oolong tea is sourced from the Guan Yin mountains.
Cat’s claw is named for its distinctive claw-like thorns, which project from the base of its leaves. PTI-00703® Cat’s claw is a proprietary aqueous extract obtained from the Peruvian rain forest woody vine (also known as Uncaria tomentosa or Uña de gato). This slow-growing woody vine is indigenous to the Amazon rain forest and other tropical areas of South and Central America.
The Cat’s claw bark in Percepta® hails from Peru, home to the Machu Picchu mountain range.
Cat's claw, the source for our PTI-00703®
Cat's claw, the source for our PTI-00703®
It is referred to as Cat’s claw due to its distinctive claw-like thorns, which project from the base of its leaves. The plant, Uncaria tomentosa can take up to 20 years to reach maturity and can grow 100 feet in length as it attaches and wraps around itself and the native trees. Both the bark and the roots of this vine have been used historically by the Aquerana, Ashaninka, Cashibo, Conibo and Shipibo tribes of Peru as a medicinal plant (1). Cat’s claw is a member of the plant family Rubiaceae, genus Uncaria that consists of at least 34 different species found in the tropical forests of Southeast Asia, Africa, Central and South America. The two South American species are Uncaria guanensis, a lower altitude shrub, and Uncaria tomentosa, a higher altitude woody vine found particularly in Peru (1).
It is the inner bark that is harvested of the plant and used for as PTI-00703® Cat’s claw, which regrows and therefore does not pillage the rain forest. Uncaria tomentosa is believed to contain beneficial phytochemicals including oxindole alkaloids(2-4), quinovic acid glycosides(5), flavonoids(6-7), triterpines(8), and the plant sterols beta-sitosterol, stigmasterol, and campesterol(8). Uncaria tomentosa also has anti-oxidant properties, a desired characteristic optimal for combating free radicals(1).
The Cat’s claw in Percepta® is harvested in a way that allows the plants to continue to grow and thrive
In the past, Cat’s claw was sold in the Peruvian market place as bark bundles to make a tea that was found to have anti-inflammatory properties due to the presence of oxindole alkaloids(2-3). However, the main ingredients in the proprietary PTI-00703® Cat’s claw extract found by the Snow research team was found not to be due to the alkaloid fraction, but to another potent ingredient discovered by the Snow research team identified to be the main component responsible for potent plaque and tangle dissolving activity(9)
PTI-00703® Cat’s claw contains the most robust plaque and tangle reducing activity that has ever been seen before. The Snow research teams have now discovered the presence of specific polyphenols that contribute to the robust plaque and tangle inhibitory activity(9). The secret sauce behind PTI-00703® cat’s claw is that at least 18 different sources (companies) that produce Cat’s claw bark extract via different modes of extraction, have been tested for direct activity in reducing brain plaques and tangles. PTI-00703® Cat’s claw is the secret sauce from a distinct producer of Cat’s claw that contains the most robust plaque and tangle reducing activity that has ever been seen before (Snow et al, under review, 2020).
MemorTea®
MemorTea®
MemorTea® (a specific oolong tea extract): In the late 1990’s and early 2000’s different polyphenols were identified from a variety of sources that were thought to be important for normal brain aging and memory loss. These included polyphenols found in green tea (including: epicatechin, EGCG [epigallocatechin gallate]; epigallocatechin and epicatechin gallate (10-14); curcumin [Indian spice] (15-18); resveratrol [found in red wine] (19-21); and other polyphenols [found in grape seed extract] (22-23). The tea plant is known as Camellia sinensis and is a species of the evergreen shrub or small tree whose leaves and leaf buds are used to produce tea. It is of the genus Camellia of flowering plants in the family Theaceca.
In the late 2000’s, the Snow research team tested a variety of different teas and their polyphenol content to target brain plaques and tangles.
Camellia sinensis and its subspecies, Camellia sinensis var. assamica, are two major varieties grown today (24). White tea, yellow tea, green tea, oolong tea, pu-erh tea, and black tea are all harvested from one or the other, but are processed differently to attain varying levels of oxidation and polyphenol substance within.
The Chinese plant Camellia sinensis is a small leafed bush with multiple stems that reach a height of 3 meters. It is native to southeast China. The first tea plant to be discovered, recorded and used to produce tea 3,000 years ago; it yields the most popular teas (24).
In the late 2000’s, the Snow research team tested a variety of different teas and their polyphenol content to target brain plaques and tangles. This included the testing of green tea (unfermented or unoxidized); oolong tea (partially fermented or partially oxidized) and black tea (fully fermented or fully oxidized). They discovered that a specific oolong tea (referred to as MemorTea®) contained the most robust plaque and tangle reducing activity. By this time, they had tested the activity of oolong tea extract from at least 10 different sources. The proprietary source of MemorTea® (from the Guan Yin mountains) was found to produce the most robust plaque and tangle reducing activity from anywhere.
MemorTea® is produced and harvested from the Guan Yin mountains. Like other oolong teas, it is rich in anti-oxidants, vital vitamins and minerals such as calcium, manganese, copper, carotin, selenium, and potassium, as well as vitamin A, B, C, E and K. It also contains folic acid, niacinamide and other detoxifying alkaloids. It is developed in partially fermented processing, which provides the tea extract with numerous polyphenolic compounds and adds even more valuable health benefits. MemorTea® also contains 38.26 mg of natural caffeine (⅓ of a cup of coffee), theophylline, theobromine and L-Theanine.
The tea fermenting process, an important production stage in the process of creating Percepta’s MemorTea® ingredient.
References
2. Reinhard, K.H. Uncaria tomentosa (Wild) D.C.: Cat’s claw, una de gato, or saventaro. J. Alter. Compliment. Med. 5:143-151 1999.
3. Muhammad I., Khan, I.A., Fisher, N.H., and Fronczek, F.R. Two stereoisomeric pentacyclic oxindole alkaloids from Uncaria tomentosa: uncarine C and uncarine E. Acta Crystallog. C. 57:480-482, 2001.
4. Muhamed, A.F. et al. Effects of Uncaria tomentosa total alkaloid and its components on experimental amnesia in mice: elucidation using the passive avoidance test. J. Pharm. Pharmacol. 52:1553-1561, 2000.
5. Montoro, P., Carbone, V., Quiroz, J.D., De Simone, F., Pizza, C. Identification and quantification of components in extracts of Uncaria tomentosa by HPLC-ES/MS. Phytochem. Anal. 15:55-64, 2004.
6. Aquino, R., De Feo, V., De Simone, F., Pizza, C., and Cirino, G. Plant metabolites. New compounds and anti-inflammatory activity of Uncaria tomentosa. J. Nat. Prod. 54:453-459, 1991.
7. Heitzman, M.E., Neto, C.C., Winiarz, E, Vaisberg, A.J., and Hammond, G.B. Ethnobotany, phytochemistry and pharmacology of Uncaria (Rubiacecea). Phytochem. 66:5-29, 2005.
8. Aquino, R., De Simone, F., Vincieri, F., Pizza, C., and Gacs-Baitz, E. New polyhydroxylated triterpenes from Uncaria tomentosa. J. Nat. Prod. 53:559-564, 1990.
9. Snow et al. The Amazon rain forest plant Uncaria tomentosa (Cat’s claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles. Scientific Reports 9:561 Feb 6, 2019.
10. Kuriyama S., et al. Green tea consumption and cognitive function: a cross-sectional study from the
Tsurugaya project. Am. J. Clin. Nutr. 83:355-361, 2006.
11. Ehrnhoefer, D.E. et al. EGCG redirects amyloidogenic polypeptides into unstructured, off pathway
oligomers. Nat. Struct Mol. Biol. 15:558-566, 2008.
12. Ng T., Feng, L., Niti, M., Kua, E., and Yap, K. Tea consumption and cognitive impairment and decline in
older Chinese adults. Am. J. Clin. Nutr. 88:224-231, 2008.
13. Rezai-Zadeh, K. et al. Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated
cognitive impairment and modulates tau pathology in mice. Brain Res. 1214:177-187, 2008.
14. Hyung S., et al. Insights into anti-amyloidogenic properties of the green tea extract (-epigallocatechin-3-
gallate) toward metal-associated amyloid-β species. Proc. Natl. Acad. Sci. 110:3743-3748, 2013.
15. Lim, G.P. et al. The curry spice curcumin reduces oxidative damage and amyloid pathology in mice. J.
Neurosc. 21:8370-8377, 2001.
16. Ono, K., Hasegawa, K., Naiki, H., and Yamada, M. Curcumin has potent anti-amyloidogenic effects for β-
amyloid fibrils in vitro. J. Neurosc. Res. 75:742-750, 2004.
17. Yang, F. et al. Curcumin inhibits formation of amyloid β oligomers and fibrils, binds plaques and reduce
amyloid in vivo. J. Biol. Chem. 280:5892-5901, 2005.
18. Cole, G.M., Teter, B., and Frautschy, S.A. Neuroprotective effects of curcumin. Adv. Exp. Med. Biol.
595:197-212, 2007.
19. Russo, A. et al. Red wine micronutrients as protective agents. Life Sciences 72:2369-2379, 2003.
20. Marambaud, P., Zhao, H., and Davies, P. Resveratrol promotes clearance of amyloid-beta peptides. J. Biol.
Chem. 280:37377-37382, 2005.
21. Wang, J. et al. Moderate consumption of Cabernet Sauvignon attenuates Aβ neuropathology in a mouse
model. FASEB J. 20:2314-2320, 2006.
22. Wang, J. et al. Consumption of grape seed extract prevents amyloid-beta deposition and attenuate
inflammation in mice brains. Neurosc. Res. 1:3-14, 2009.
23. Wang, J. et al. Brain-target proanthocyanidin metabolites. J. Neurosc. 32:5144-5150, 2012.
24. https://en.wikipedia.org/wiki.Camellia_sinensis