PERCEPTA® MEMORY SUPPORT
The Discovery of Percepta®
PERCEPTA® MEMORY SUPPORT
The Discovery of Percepta®
PTI-00703® cat’s claw from the Amazon rainforest. MemorTea® from the mountains of China. The one-two punch of distinct plant extracts, and postulated inhibitors and reducers of brain “plaques and tangles” comprise Percepta®, the first nootropic to target the real reason we lose memory as we age.*
PTI-00703® cat’s claw from the Amazon rainforest. MemorTea™ from the mountains of China. The one-two punch of distinct plant extracts, and postulated inhibitors and reducers of brain “plaques and tangles” comprise Percepta®, the first nootropic to target the real reason we lose memory as we age.*
Cat’s claw (Uncaria tomentosa) is a woody vine found in the Amazon rain forest. PTI-00703® is our proprietary source of cat’s claw bark powder identified for “plaque & tangle” reducing activity.*
Cat’s claw is an ancient plant extract used for centuries by Peruvian tribes for immune support
In the early 2000’s, while a Research Associate Professor of Pathology at University of Washington, Dr. Alan Snow and his world-class research teams went on a screening expedition after they developed a proprietary assay to identify the most potent inhibitors/reducers of brain “plaques”. They screened many dietary supplements that were available in the marketplace for human consumption at the time, looking for a natural inhibitor and reducer of brain “plaques” (that accumulate in the normal aging brain).
Brain “plaques”, and then later “tangles”, were the two main culprits identified to be the actual cause of normal memory loss as one gets older. The Snow neuroscience team, while at the University of Washington, identified an ancient plant extract known as Uncaria tomentosa (cat’s claw) that was used for centuries by the Peruvian tribes for immune support and enhancement1-2.The cat’s claw ingredient was found to be a potent inhibitor and disrupter of brain “plaques” (that consisted of a protein called “beta-amyloid protein”)3-5. The Snow research teams spent years screening different sources to identify the specific, proprietary cat’s claw that produces the most potent activity against brain “plaques”: PTI-00703® cat’s claw4-6.
Dr. Snow and his research teams have now identified the specific and newly discovered polyphenol ingredients within PTI-00703® cat’s claw that are responsible for the potent activity that they first identified. These ingredients and the exact mechanism of action of how this amazing plant extract works to reduce brain plaque load and improve memory will soon be published for the world to see7.
MemorTea® is our proprietary source of Oolong tea (Camellia sinensis) identified for “plaque & tangle” reducing activity.*
Years later, the Snow research teams also developed appropriate models to recapitulate brain “tangles” (consisting of a protein called “tau protein”) in a test-tube, the other part of the spectrum of memory loss in normal individuals. Since at the time, various peer-reviewed publications were touting the potential use of green tea and their specific polyphenol components as inhibitors and disrupters of “plaques and tangles”8-13.
The one-two punch of distinct plant extracts, and postulated inhibitors and reducers of brain “plaques and tangles,” make up Percepta®
The Snow research team then screened different kinds of teas including green tea (not oxidized or fermented), oolong tea (partially oxidized or fermented), and black tea (totally oxidized or fermented), from various sources to also identify the most robust inhibitor/ disrupter of both brain “plaques and tangles”. They then identified a specific and proprietary “oolong tea” (known as “MemorTea®”) from a secret source, found to reduce and inhibit “plaques and tangles” as well.
This one-two punch of two distinct plant extracts and postulated inhibitors and reducers of brain “plaques and tangles” make up the innovative synergistic components of Percepta®. Percepta®is the world’s first natural plant-derived nootropic to target brain “plaques and tangles” for memory support and enhancement.*
Dr. Alan Snow has joined forces with Dr. Rudolph Tanzi (one of the world’s most foremost authorities on brain aging) to form Cognitive Clarity Inc. for the development of “Breakthrough Nutraceuticals for the Aging Brain.”
Percepta® has thus been specifically formulated and developed by two of the world’s most renowned authorities on brain aging.
- Reinhard, K.H. Uncaria tomentosa (Wild) D.C.: cat’s claw, una de gato, or saventaro. J. Alter. Compliment. Med. 5:143-151, 1999.
- Muhammad, I., Khan, I.A., Fisher, N.H., and Fronczek, F.R. Two stereoisomeric pentacyclic oxindole alkaloids from Uncaria tomentosa: uncarine C and uncarine E. Acta Crystallog. C. 57:480-482, 2001.
- McCurley, D., Castillo, G.M. and Snow A.D. Therapeutic implications of PTI-00703®. Presentation at the 6th International conference, Amsterdam, July 18-23, 1998.
- Castillo, G.M., Cummings, J.A., and Snow, A.D. Further efficacy of PTI-00703®: A derivative from the amazon rain forest woody vine Uncaria tomentosa (cat’s claw) that is a potent inhibitor of beta-amyloid protein fibrillogenesis. Oral presentation at the 29th Annual Meeting Society for Neuroscience, Miami, Florida, Oct 23-28, 1999.
- Castillo, G.M., Kirchner, D.A., Yee, A.G., and Snow, A.D. Electron microscopy and x-ray diffraction studies confirm the efficacy of PTI-00703® (cat’s claw derivative) as a potent inhibitor of beta-amyloid protein fibrillogenesis. Oral Presentation at the World Congress 2000, Washington, DC, July 9-13, 2000.
- Castillo G.M., Kirschner D.A., Yee A.G., and Snow A.D. Electron microscopy and x-ray diffraction studies further confirm the efficacy of PTI-00703® (Cat’s claw derivative) as a potential inhibitor of beta-amyloid protein fibrillogenesis. The Proceedings of the 7th International Conference, edited by K. Iqbal, S.S. Sisodia, and B. Winblad, John Wiley & Sons, pp. 450-460, 2001.
- Snow et al. Identification of the natural plant Uncaria tomentosa (cat’s claw) and specific small molecule phenolic components identified within as potent inhibitors and disrupters of brain “plaques and tangles”: Potential for a new nutraceutical treatment for normal brain aging. In Press, 2018.
- Kuriyama, S., et al. Green tea consumption and cognitive function: a cross-sectional study from the Tsurugaya project. Am. J. Clin. Nutr. 83:355-361, 2006.
- Ehrnhoefer, D.E. et al. EGCG redirects amyloidogenic polypeptides into unstructured, off- pathway oligomers. Nat. Struct. Mol. Biol. 15:558-566, 2008.
- Ng, T., Feng, L., Niti, M., Kua, E., and Yap, K. Tea consumption and cognitive impairment and decline in older Chinese adults. Am. J. Clin. Nutr. 88:224-231, 2008.
- Rezai-Zadeh, K. et al. Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in mice. Brain Res. 1214:177-187, 2008.
- Hyung S., et al. Insights into anti-amyloidogenic properties of the green tea extract (-epigallocatechin-3-gallate) toward metal-associated amyloid-β species. Proc. Natl. Acad. Sci.110:3743-3748, 2013.
- Wobst, H.J., Sharma, A., Diamond, M.I., Wanker, E.E., and Bieshke, J. The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substiochiometric ratios. FEBS Letters 589:77-83, 2015.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to treat, diagnose, cure or prevent any disease.